The Clinical and Translational Research Center (CTRC) was initiated in 2006 as a major component of the Clinical and Translational Science Award (CTSA), an NIH Roadmap initiative. The CTRC merged the General Clinical Research Centers (GCRCs) at the Children's Hospital of Philadelphia (CHOP) and University of Pennsylvania Health System (UPHS), and introduced new programs and services. The CTRC has child and adult specific facilities at the Children's Hospital of Philadelphia (CHOP) and University of Pennsylvania Health System (UPHS), respectively, as well as joint components. The CHOP CTRC Program Director, Carole Marcus, MBBCh, can be contacted at marcus@email.chop.edu.

It is very important for Investigators to contact the CTRC Adminstrative Director, Ronnie Kain at kainv@email.chop.edu or 215-590-2215, prior to submitting external grant applications. Please click for more information: grant submissions

Visit CTRC main website here or through the links below.

Services and Facilities

The goal of the CTRC is to provide the resources, environment, operations, and training to support and promote high-quality clinical and translational research by qualified investigators.

The CTRC supports the research of more than 300 different principal investigators from Penn and CHOP engaged in over 400 research protocols. All protocols are approved by the CTRC Resource Committees.

Research Nursing Core

CHOP Specific Procedures for CTRC Research Nursing Core (RNC)

The Clinical and Translational Research Center (CTRC) is staffed by experienced, qualified research nurses for inpatient and outpatient activities. The nurses, medical assistants and lab techs support a wide variety of research protocols. CHOP CTRC Nursing support is available at two outpatient locations at Main and 3550 Market Street, the CTRC Inpatient Unit on 5 West, and other CHOP inpatient units as necessary.

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Nutrition Core

The Nutrition Core has two components. The Nutrition Assessment Unit is a state-of-the-art facility for the assessment of growth and body dimensions, body composition (the amount of muscle, fat and bone in the body), energy expenditure, bone density, and muscle strength. The Core provides consultation and technical expertise for these assessments. The Unit has two locations and four experienced research technicians for performing nutrition assessments. The Dietary Assessment Unit is staffed by experienced registered dietitians and provides a broad range of nutrition-related research services to investigators.

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Sleep Core

The CTRC Sleep Core provides services in support of clinical sleep research. It is based at two sites: the CHOP Sleep Laboratory, convenient to the CTRC Outpatient Facility on the First Floor of Main Hospital and the University of Pennsylvania's Sleep Laboratory, located on the 11th Floor of the Gates Building which is part of the medical complex of the Hospital of the University of Pennsylvania. The Sleep Core contains a total of six designated research beds, dedicated staff, and state-of-the-art equipment that provides support for a variety of sleep-related research initiatives.

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Cardiovascular Core

The CTRC Cardiovascular Core provides cardiac testing services at CHOP for pediatric subjects in the Main Building. Services for adult subjects MUST be discussed with the CTRC Cardiovascular Core Director, Dr. Meryl Cohen, MD.

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Pulmonary Core

The Pulmonary Core provides pulmonary function testing in laboratories of the Children's Hospital of Philadelphia (CHOP) allowing for comprehensive pulmonary testing of pediatric subjects.

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Behavioral Neuroscience Core

The Behavioral Neuroscience Core provides consultation and assistance to investigators regarding psychological, neuropsychological, and psychiatric components of research studies involving pediatric subjects. The Core is highly experienced in implementing multisite protocols. We provide test kits, test record forms, and scoring software at no additional charge to the investigators for whom we provide testing services. When investigators are considering work with the Neurobehavioral Core, it is helpful to provide a copy of the protocol prior to submission, so that our Core can determine our ability to conduct testing and procedures that are called for, as well as to give estimates as to the costs for each study evaluation.

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Study Design and Biostatistics

Study Design and Biostatistics provides research study planning and analytic services, such as study design, sample size estimation, analysis planning, as well as production of statistical reports and graphical displays.

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Informatics Core

The Informatics Core provides assistance with database development and CRF form development and other computing needs.

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Ophthalmology Core

The Clinical and Translational Research Center (CTRC) offers ophthalmological testing services for children. The Ophthalmology Core at CHOP's CTRC was established to provide clinical and translational research services in ophthalmology for the assessment of visual function and structure.

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Pediatrics Research Consortium (PeRC)

The Pediatrics Research Consortium (PeRC) supports effective research within the Children’s Hospital community by coordinating our extensive practice-based research network (PBRN). We cater to the diverse needs of the three main parties that benefit from practice-based research: 1) Researchers, 2) Care Centers and Practices, and 3) Patients and Families.

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Neuromonitoring Core

This core provides 2 new services: (1) state of the art continuous neuromonitoring and (2) Cerebral diffuse optical monitoring for clinical and translational research purposes. The Neuromonitoring Core leaders guide researchers in use of the tools and incorporation of the tools into their research projects. The Core implements research of the vulnerable brain along two paths.

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