Technologies for Licensing
Children's Hospital has technologies available for license in a number of categories and actively seeks partners for licensing opportunities. Explore the links below to learn more about the available technologies.
- Delivery
- Cholesterol modified polyurethanes that enhance cell adhesion to devices
- Magnetically-driven biodegradable gene delivery nanoparticles in surface-attached polycationic complex
- Retention of endothelial cells on vascular grafts
- Surface activation of implantable medical devices for attaching molecular therapies using multipoint benzophenone photo-cross-linkers absorbed from aqueous media
- Functionalized coatings for metal surfaces for biomedical uses
- Cell delivery systems with high affinity binding for implants, cell-surface targeting, homing, stress resistant adhesion, patterning and cell-cell, cell-matrix alignment and association
- Chemicals
- Gene Therapy
- Gene vector delivery from stents using a coordination bonding strategy
- Gene-based approach for treatment of bleeding disorders using a bypass strategy
- Gene and cell delivery via self-expanding polymer stents
- Virus containing hydrogels for controlled viral gene therapy
- The use of receptor sequences for immobilizing gene vectors on surfaces
- Compositions and methods for performing reverse gene therapy
- Mini Factor VIII gene for the treatment of Hemophilia A
- Non-viral vehicles for treatment of Cystic Fibrosis
- Methods for production of chimeric AAV vectors
- Cytoskeletal and extracellular matrix mechanisms to control gene therapy
- Controlled Release of Genes for Localized Delivery
- Sustained release preparations composed of biocompatible, injectable, nanoscopically-sized complexes of angiogenic growth factors, PDGF and VEGF, with dextran sulfate prepared by complex coacervation
- Nucleic Acid
- Device
- Functionalized polymeric colloids
- Child-safe handlebar
- Alpha-hemoglobin stabilizing protein (AHSP) and recombinant hemoglobin production in E. coli
- Biodegradable linkers for molecular therapies
- Steroid-embedded Gastrostomy Tube
- Respiratory volume/flow gating, monitoring, and spirometry systems for MRI
- Occupant protection for sleeping children
- Retention of endothelial cells on vascular grafts
- Functionalized coatings for metal surfaces for biomedical uses
- A foot retractor for surgical procedures on the foot and ankle
- Novel polyesters
- Stabilization of implantable bioprosthetic devices
- Steroid-eluting, low profile enteral feeding tube
- Fast dynamic imaging protocol using a multi-head photon emission computed tomography system
- Magnetically-driven biodegradable gene delivery nanoparticles in surface-attached polycationic complex
- Mandibular occlusal inhibitor
- Robotically Controlled Laser For Use In Rose Bengal Injury Model
- Novel thiol activation of polyurethanes and quantitative methodology
- Diversion technology for blood-drawing in children
- A Multi-Wavelength Frequency Domain Near-Infrared Cerebral Oximeter
- Gene and cell delivery via self-expanding polymer stents
- Retrofit Child-Safe Handlebar
- Doll used for instruction of Sickle Cell Disease clinical observations
- Sleeping occupant protection system for vehicles
- Diagnostics
- Compositions and diagnostic kits for identifying Alveolar Rhabdomyosarcoma
- Methods to screen for neurotoxicity using a clonal human teratocarcinoma cell line
- Biomarkers
- Molecular diagnostic for Cornelia de Lange Syndrome
- Amplification of breakpoint regions in DNA
- Human leucine-zipper protein kinase and methods of use
- A molecular marker for diagnosis of late-stage tumor progression
- CHD5, a new member of the Chromodomain gene family, preferentially expressed in the nervous system
- Nitrated fibrinogen as a marker for coronary artery disease
- Imaging
- Nucleic Acid Based
- Nanotechnology
- Public Safety
- Research Tools
- Methods and compositions for detecting the replication of plus-stranded RNA viruses and for screening potential replication inhibitors
- Methods for producing ex vivo models for inflammatory disease and uses thereof
- The use of receptor sequences for immobilizing gene vectors on surfaces
- Robotically Controlled Laser For Use In Rose Bengal Injury Model
- Utilization of cell culture systems for determining the cholesterol efflux potential of serum
- New Artificial Membrane Systems for the Identification and Evaluation of Interactions between Membrane-Anchored Ligands and Receptors
- Methods for production of chimeric AAV vectors
- Alpha-hemoglobin stabilizing protein (AHSP) and recombinant hemoglobin production in E. coli
- Cell-based assay for measurement of net cholesterol flux
- Sets of oligo primers/probes for real time PCR to quantify expression of Bcl-2-related protein family genes
- Novel Endopeptidase
- Software
- Therapeutic
- CYP3A4 NFSE variant and methods of use
- Transcriptional repression as a therapeutic target in epileptogenesis
- Prevention of HIV latency with activation of STAT5
- Compositions and diagnostic kits for identifying Alveolar Rhabdomyosarcoma
- Haemophilus influenzae vaccine with opacity associated proteins OapA and OapB
- Retention of endothelial cells on vascular grafts
- Methods for production of chimeric AAV vectors
- Novel methods for treatment of Fontan operation patients with protein losing enteropathy
- Virus containing hydrogels for controlled viral gene therapy
- Blood and Lymphatic System
- Suppression of inhibitor formation in Hemophilia B
- Mini Factor VIII gene for the treatment of Hemophilia A
- Ectopic expression of urinary plasminogen activator (uPA) in platelets as a novel anti-thrombotic strategy
- Enhanced gamma-carboxylation of recombinant Vitamin K-dependent clotting factors
- Gene-based approach for treatment of bleeding disorders using a bypass strategy
- Strategy for creating anti-thrombocytes in vitro
- Alpha-hemoglobin stabilizing protein (AHSP) and recombinant hemoglobin production in E. coli
- Cancer
- Ion Channel Forming Peptides
- GRP94-Based Compositions and Methods of Use Thereof
- Use of angiogenesis inhibitors post bone marrow transplant to treat patients in minimal residual disease
- CHD5, a new member of the Chromodomain gene family, preferentially expressed in the nervous system
- Use of M-tor inhibitors in the treatment of Acute Lymphocytic Leukemia
- Cardiovascular and Circulatory System
- Central Nervous System
- Infections
- Neurokinin-T receptor antagonist inhibits HIV-1 infection of human mononuclear phagocytes in vitro
- Treatment for Haemophilus influenzae infection
- Ion Channel Forming Peptides
- GRP94-Based Compositions and Methods of Use Thereof
- HIV-related cellular gene DA3 and uses thereof
- New treatment for Streptococcus pneumoniae infection
- Metabolic / Endocrinology
- Respiratory and Pulmonary System