Hakon Hakonarson, MD, PhD

  • Department: Pediatrics
  • Division: Human Genetics and Molecular Biology
  • Email: hakon2@mail.med.upenn.edu
  • Primary Address:
    The Joseph Stokes Jr. Research Institute, Room 1216E
    The Children's Hospital of Philadelphia
    3615 Civic Center Blvd.
    Philadelphia, PA 19104
  • 590-3469

    Expertise

    Dr. Hakonarson is investigating genetic factors that underlie complex medical disorders in children and adults.

    Appointments

    Associate Professor of Pediatrics, University of Pennsylvania School of Medicine (2008 – present)
    Adjunct Assistant Professor of Pediatrics, University of Pennsylvania School of Medicine (1999 – 2008)
    Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia (1996 – 1998)

    Education

    PhD, University of Iceland, School of Medicine (2002)
    MD, University of Iceland, School of Medicine (1986)

    Selected Publications

    Hakonarson H, Kim C, Whelan R, Leiter J, Campbell D.. T Lymphocyte-Induced Changes in Airway Smooth Muscle Responsiveness are Attributed to Autocrine Release and Interactions of Interleukin (IL)-5 and IL-1beta.. J Immunol (Submitted for Publication), 2000. .
    Hakonarson H, Carter C, Kim C, Grunstein MM.. Regulation and Action of the Low-Affinity IgE Receptor, Fc RII (CD23), in Asthmatic Airways Smooth Muscle.. J Allerg Clin Immunol, 1999, in Altered Responsiveness of Atopic Asthmatic Sensitized Airway Smooth Muscle. J Clin Invest, 1997. Vol 99. 117-124.
    Arnar DO, Thorvaldsson S, Manolio TS, Thorgeirsson G, Stefansson K, Hakonarson H.. Evidence of heritability of atrial fibrillation is stronger among patients under age of 60 years than those over 60.. .
    Edvardsson V, Thoroddsson S, Palsson R, Indridason OS, Kristjansson K, Stefansson K, Hakonarson H.. Genetic Contribution to Calcium Kidney Stone Disease.. .
    Gottfredsson M, Thorvaldsson S, Jonsson T, Kristjansson MS, Kristjansson K, Love A, Blondal T, Kristinsson KG, Stefansson K, Hakonarson H, Gulcher JR.. Lessons from the past: Familial aggregation analysis of fatal pandemic influenza (Spanish flu) in 1918.. .
    Blakey JD, Halapi E, Hakonarson H, Hall IP.. Linkage Analysis for Nicotine Dependence: New Data and Meta-analysis.. .
    Andersen K, Haraldsdottir S, Sigurdsson AF, Eyjolfsson K, Gudnason T, Scheving S, Jonsdottir B, Hakonarson H.. In-Stent Restenosis can be accurately predicted by 64-slice MDCT scan.. .
    Devoto M, Baldassano RN, Bradfield JP, Monos DS, Kim CE, Glessner JT, Casalunovo T, Frackelton EC, Otieno FG, Kanterakis S, Shaner JL, Smith RM, Eckert AW, Robinson LJ, Onyiah CC, Abrams DJ, Chiavacci RM, Skraban R, Grant SFA, Hakonarson H.. Association of variants of the IL23R and ATG16L1 genes with susceptibility to pediatric Crohn's disease.. .
    Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Capasso M, Skraban R, Lu Y, Chiavacci RM, Stanley CA, Kirsch SE, Rappaport EF, Orange JS, Monos DS, Devoto M, Qu HQ, Polychronakos C.. A pediatric genome-wide association study identifies a novel Type 1 diabetes gene.. .
    Kanterakis S, Roeder K, Kui S, Bradfield J, Grant SFA.. Long-range computational haplotyping of the Human Major Histocompatibility Complex reveals insufficiency of current computational methods for accurate haplotype reconstruction.. .
    Shaikh TH, Gai X, Perin J, Rappaport E, White PS, Grant S, Shaffer L, Saitta S, Zackai EH, Hakonarson H.. Copy number variation in human genomic disorders.. .
    Wang K, Hadley D, Liu R, Glessner J, Kim J, Li M, Hakonarson H, Bucan M.. Genetic analysis of copy number variation in autism families.. .
    Spinner NB, Greco AJ, Thiel BT, Glessner J, Munoz P, Gai X, Piccoli DA, Hakonarson H, Krantz ID, Kamath BM.. SNP array mapping of 20p deletions: genotypes, phenotypes and copy number variation.. .
    Wang K, Li M, Hadley D, Liu R, Glessner J, Grant S, Kim J, Hakonarson H, Bucan M.. High-resolution copy number variation detection: application of an integrated hidden Markov Model on Illumina whole-genome SNP genotyping data.. .
    Hakonarson H, Grant SFA, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Capasso M, Skraban R, Chiavacci RM, Stanley CA, Kirsch SE, Monos DS, Devoto M, Qu HQ, Polychronnakos C.. A Genome-Wide Association Study Identifies a Novel Type 1 Diabetes Gene.. .
    Shan X, Chuang S, Hakonarson H, Grunstein MM.. Induction of the Pro-Asthmatic Phenotype in Airway Smooth Cells Transfected to Over-Express CD23.. .
    Hakonarson H, Steinsen H.. Remitting Seronegative Symmetrical Synovitis with Pitting Edema.. Icel Med J. Vol 75. 1989:187-189.
    Steinsen H, Hakonarson H.. Reiters Syndrome, Long-term Prophylactic Antibiotic Therapy.. Icel Med J. Vol 77. 1991:319-323.
    Hakonarson H, Moskovitz J, Daigle KL, Cassidy SB, Cloutier MM.. Pulmonary function abnormalities in Prader-Willi syndrome.. J Pediatr. Vol 126. 1995:565-70.
    Hakonarson H, Herrick DJ, Grunstein MM.. Mechanism of impaired beta-adrenoceptor responsiveness in atopic sensitized airway smooth muscle.. Am J Physiol (Lung Cell Mol Physiol). Vol 269. 1995:L645-652.
    Hakonarson H, Herrick DJ, Gonzalez-Serrano PG, Grunstein MM.. Mechanism of cytokine-induced modulation of beta-adrenoceptor responsiveness in airway smooth muscle.. J Clin Invest. Vol 97. 1996:2593-2600.
    Hakonarson H.. Asthma.. In: The Five Minute Pediatric Consult. Williams and Wilkins; 1996:126-129.
    Hakonarson H.. Bronchiolitis.. In: The Five Minute Pediatric Consult. Williams and Wilkins; 1996:178-180.
    Hakonarson H.. Apnea.. In: The Five Minute Pediatric Consult. Williams and Wilkins; 1996:110-112.
    Hakonarson H, Kravitz RM.. Hemoptysis.. In: Clinical Handbook of Pediatrics (CHOP). Williams and Wilkins; 1996 (2nd edition, 1999):344-352.
    Hakonarson H, Grunstein MM.. Management of Childhood Asthma.. In: Asthma. Vol 2(126) . Raven Press; 1997:1847-1868.
    Hakonarson H, Herrick DJ, Gonzalez-Serrano PG, Grunstein MM.. Autocrine role of interleukin 1beta in altered responsiveness of atopic asthmatic sensitized airway smooth muscle.. J Clin Invest. Vol 99. 1997:117-124.
    Hakonarson H, Grunstein MM.. Autologously up-regulated Fc receptor expression and action in airway smooth muscle mediates its altered responsiveness in the atopic asthmatic sensitized state.. Proc Natl Acad Sci USA. Vol 95. 1998:5257-5262.
    Hakonarson H, Maskeri N, Carter C, Hodinka RL, Campbell D, Grunstein MM.. Mechanism of rhinovirus-induced changes in airway smooth muscle responsiveness.. J Clin Invest. Vol 102. 1998:1732-1741.
    Hakonarson H, Grunstein MM.. Regulation of second messengers associated with airway smooth muscle contraction and relaxation.. Am J Respir Crit Care Med. Vol 158. 1998:S115-S122.
    Rajah R, Nachajon RV, Collins MH, Hakonarson H, Grunstein MM, Cohen P.. Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle.. Am J Respir Cell Mol Biol. Vol 20. 1999:199-208.
    Hakonarson H, Carter C, Maskeri N, Kim C, Grunstein MM.. Regulation of TH1- and TH2-type cytokine expression and action in asthmatic sensitized airway smooth muscle.. J Clin Invest. Vol 103. 1999:1077-1087.
    Hakonarson H, Carter C, Maskeri N, Hodinka R, Grunstein MM.. Rhinovirus-mediated changes in airway smooth muscle responsiveness: induced autocrine role of interleukin-1beta.. Am J Physiol (Lung Cell Mol Physiol 21). 1999:L13-L21.
    Hakonarson H, Maskeri N, Kim C, Grunstein MM.. Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle.. J Clin Invest. Vol 104. 1999:657-667.
    Hakonarson H, Carter C, Kim C, Grunstein MM.. Regulation and Action of the Low-Affinity IgE Receptor, Fc RII (CD23), in Asthmatic Airway Smooth Muscle.. J Allergy Clin Immunol. Vol 104. 1999:575-584.
    Hakonarson H.. Medical Research. Business or Science. Collaboration between Academia and Industry.. Icel Med J. Vol 85(9). 1999:737-741.
    Grunstein MM, Hakonarson H, Maskeri N, Kim C, Chuang S.. Intrinsic ICAM-1/LFA-1 activation mediates altered responsiveness of atopic asthmatic airway smooth muscle.. Am J Physiol Lung Cell Mol Physiol. Vol 278. 2000 Jun:L1154-63.
    Grunstein MM, Hakonarson H, Maskeri N, Kim C, Chuang S.. Autocrine cytokine signaling mediates effects of rhinovirus on airway responsiveness.. Am J Physiol Lung Cell Mol Physiol. Vol 278(6). 2000 Jun:L1146-53.
    Grunstein MM, Hakonarson H, Hodinka RL, Maskeri N, Kim C, Chuang S.. Mechanism of cooperative effects of rhinovirus and atopic sensitization on airway responsiveness.. Am J Physiol Lung Cell Mol Physiol. Vol 280(2). 2001 Feb:L229-38.
    Grunstein MM, Hakonarson H, Leiter J, Chen M, Whelan R, Grunstein JS, Chuang S.. Autocrine signaling by IL-10 mediates altered responsiveness of atopic sensitized airway smooth muscle.. Am J Physiol Lung Cell Mol Physiol. Vol 281(5). 2001 Nov:L1130-7.
    Hakonarson H, Kim C, Whelan R, Campbell D, Grunstein MM.. Bi-directional activation between human airway smooth muscle cells and T lymphocytes: role in induction of altered airway responsiveness.. J Immunol. Vol 166(1). 2001 Jan:293-303.
    Grunstein MM, Hakonarson H, Whelan R, Yu Z, Grunstein JS, Chuang S.. Rhinovirus elicits proasthmatic changes in airway responsiveness independently of viral infection.. J Allergy Clin Immunol. Vol 108(6). 2001 Dec:997-1004.
    Hakonarson H, Bjornsdottir US, Ostermann E, Arnason T, Adalsteinsdottir AE, Halapi E, Shkolny D, Kristjansson K, Gudnadottir SA, Frigge ML, Gislason D, Gislason T, Kong A, Gulcher J, Stefansson K.. Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland.. Am J Respir Crit Care Med. Vol 164(11). 2001 Dec:2036-44.
    Hakonarson H, Halapi E, Whelan R, Gulcher J, Stefansson K, Grunstein MM.. Association between IL-1beta/TNF-alpha-induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle.. Am J Respir Cell Mol Biol. Vol 25(6). 2001:761-71.
    Hakonarson H, Thorsson A.. Common causes of sleep disturbances in Icelandic children who undergo sleep studies.. Laeknabladid. Vol 87(10). 2001:799-804.
    Agustsson TT, Hakonarson H, Olafsson I, Hjaltadottir G, Thornorsson AV.. A mutation detection in a transcription factor for adipocyte development in children with severe obesity.. Laeknabladid. Vol 87(2). 2001:119-124.
    Hakonarson H, Wjst M.. Current concepts on the genetics of asthma.. Curr Opin Pediatr. Vol 13. 2001:267-77.
    Hakonarson H, Halapi E.. Genetics of obstructive airways disease: Cystic fibrosis, alpha-1 antitrypsin deficiency and Hermansky Pudlak syndrome.. Immunol Allergy Clin North Am. 2002:243-60.
    Hakonarson H, Halapi E.. Current Understanding of the Genetics of Asthma: Clinical Implications.. Am J Pharmacog. Vol 2. 2002:155-166.
    Halapi E, Hakonarson H.. Advances in the Development of Genetic Markers for the Diagnosis of Disease and Drug Response.. Expert Rev Mol Diagn. Vol 2. 2002:411-21.
    Grunstein MM, Hakonarson H, Leiter J, Chen M, Whelan R, Grunstein JS, Chuang S.. IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle.. Am J Physiol Lung Cell Mol Physiol. Vol 282. 2002:L520-8.
    Hakonarson H, Kim C, Whelan R, Grunstein MM.. T lymphocyte-mediated changes in airway smooth muscle responsiveness are attributed to induced autocrine actions and release of IL-5 and IL-1beta.. J Allergy Clin Immunol. Vol 110. 2002:624-33.
    Gislason T, Johannsson JH, Haraldsson A, Olafsdottir BR, Jonsdottir H, Kong A, Frigge ML, Jonsdottir GM, Hakonarson H, Gulcher J, Stefansson K.. Familial predisposition and cosegregation analysis of adult obstructive sleep apnea and the sudden infant death syndrome.. Am J Respir Crit Care Med. Vol 166. 2002:833-8.
    Hakonarson H, Bjornsdottir US, Halapi E, Palsson S, Adalsteinsdottir E, Gislason D, Finnbogason G, Gislason T, Kristjansson K, Arnason T, Birkisson I, Frigge ML, Kong A, Gulcher JR, Stefansson K.. A major susceptibility gene for asthma maps to chromosome 14q24.. Am J Hum Genet. Vol 71. 2002:483.
    Hakonarson H, Whelan RS, Leiter JA, Kim C, Grunstein MM.. Induction of Pro-Asthmatic Cytokine Expression and Production in T-Lymphocytes By Activated Human Airway Smooth Muscle Cells.. Am J Respir Crit Care Med. 2003.
    Hakonarson H, Whelan RS, Leiter JA, Grunstein MM.. Upregulated NFATc and STAT5A Expression is Coupled to Induced Release and Autocrine Action of TH2- and Proinflammatory Cytokines in T-Lymphocyte-Activated Human Airway Smooth Muscle Cells.. Am J Respir Crit Care Med. 2003.
    Hakonarson H, Gulcher J, Stefansson K.. deCODE genetics Inc.. Pharmacogenomics. Vol 4. 2003:209-215.
    Hakonarson H, Stefansson K.. Emerging diagnostic and drug discovery platforms for common complex disease.. Current Drug Discovery. 2003 Mar:25-29.
    Hakonarson H, Grunstein MM.. Autocrine Role of Airway Smooth Muscle in Asthma.. Respir Physiol Neurobiol. Vol 137. 2003:263-76.
    Halapi E, Hakonarson H.. Recent Development in Genomic and Proteomic Research for Asthma.. Curr Opin Pulm Med. Vol 10. 2003:22-30.
    Halapi E, Stefansson K, Hakonarson H.. Population Genomics of Drug Response.. Am J PharmacoGenomics. Vol 4. 2004:73-82.
    Hakonarson H, Stefansson K.. Role of Pharmacogenomics in Drug Development.. Drug Dev Research. Vol 62. 2004:86-96.
    Hakonarson H, Halapi E, Sigvaldason A, Jonsson H, Gislason T, Andrason H, Kong A, Gulcher JR, Stefansson K.. A linkage study in heavy smokers identifies both causative and protective genes for chronic obstructive pulmonary disease.. Am J Respir Crit Care Med. 2004.
    Halapi E, Bjornsdottir US, Upmanyu R, Jonsson H, Soebech BA, Gislason D, Kristinsson S, Gislason T, Kong A, Gulcher R, Stefansson K, Hakonarson H.. Genome-wide search in asthma and atopy patients in Iceland identifies multiple loci of genome-wide significance but fails to identify linkage or association to the ADMA33 locus on chr 20p.. Am J Respir Crit Care Med. 2004.
    Arnar DO, Thorvaldsson S, Manolio T, Thorgeirsson G, Stefansson K, Hakonarson H.. Familial aggregation of atrial fibrillation in Iceland.. Am J Hum Genet. 2004.
    Karason A, Steinsson K, Hauksson VB, Halapi E, Jonsson H, Jonsdottir G, Gulcher J, Stefansson K, Hakonarson H.. Genome-Wide significant Non-MHC locus in Rheumatoid Arthritis families from Iceland.. Am J Hum Genet. 2004.
    Laufs J, Andrason H, Sigvaldason A, Halapi E, Thorsteinsson L, Jonasson K, Soebech E, Gislason T, Gulcher JR, Stefansson K, Hakonarson H.. Association of Vitamin D Binding Protein Variants with Chronic Mucus Hypersecretion in Iceland.. American Journal of PharmacoGenomics. Vol 4(1) . 2004:63-68(6).
    Helgadottir A, Manolescu A, Thorleifsson G, Gretarsdottir S, Jonsdottir H, Thorsteinsdottir U, Samani NJ, Gudmundsson G, Grant SF, Thorgeirsson G, Sveinbjornsdottir S, Valdimarsson EM, Matthiasson SE, Johannsson H, Gudmundsdottir O, Thorhallsdottir M, Andresdottir M, Frigge ML, Topol EJ, Kong A, Gudnason V, Hakonarson H, Gulcher JR, Stefansson K.. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.. Nat Genet, online. 2004 Feb.
    Birkisson IF, Halapi E, Bjornsdottir US, Shkolny DL, Adalsteinsdottir E, Arnason T, Gislason D, Gislason T, Gulcher J, Stefansson K, Hakonarson H.. Genetic approaches to assessing evidence for a T helper type 1 cytokine defect in adult asthma.. Am J Respir Crit Care Med. 2004 May.
    Whelan R, Kim C, Leiter J, Grunstein MM, Hakonarson H.. Role and regulation of IL-1 molecules in pro-asthmatic sensitized airway smooth muscle.. Eur Respir J. Vol 24. 2004:559-67.
    Pack AI, Gislason T, Hakonarson H.. Linkage to apnea-hypopnea index across the life-span: is this a viable strategy?. Am J Respir Crit Care Med. Vol 170. 2004:1260.
    Helgadottir A, Gretarsdottir S, St Clair D, Manolescu A, Cheung J, Thorleifsson G, Pasdar A, Grant SF, Whalley LJ, Hakonarson H, Thorsteinsdottir U, Kong A, Gulcher J, Stefansson K, Macleod MJ.. Association between the Gene Encoding 5-Lipoxygenase-Activating Protein and Stroke Replicated in a Scottish Population.. Am J Hum Genet. Vol 7. 2005:76.
    Blakey J, Halapi E, Bjornsdottir US, Wheatley A, Kristinsson S, Upmanyu R, Stefansson K, Hakonarson H, Hall IP.. Contribution of ADAM33 polymorphisms to the population risk of asthma.. Thorax. Vol 60(4). 2005:274-6.
    Hakonarson H, Thorvaldsson S, Helgadottir A, Gudbjartsson D, Zink F, Andresdottir M, Arnar DO, Andersen K, Sigurdsson A, Thorgeirsson G, Jonsson A, Agnarsson U, Bjornsdottir H, Adalsteinsdottir AE, Kristjansson K, Hardarson T, Kristinsson A, Topol EJ, Gulcher J, Kong A, Gurney M, Thorgeirsson G, Stefansson K.. A randomized, placebo-controlled, crossover trial of an inhibitor of the 5-lipoxygenase activating protein (FLAP), DG-031, shows reduction in concentrations of biomarkers of risk of myocardial infarction in patients with coronary artery disease and at-risk variants of the FLAP and leukotriene A4 (LTA4) hydrolase genes.. JAMA. Vol 293. 2005:2245-56.
    Hakonarson H, Bjornsdottir US, Halapi E, Bradfield J, Zink F, Helgadottir H, Bjarkarson I, Arnason T, Thorarinsson F, Gudmundsdottir AS, Ingvarsson S, Amundadottir L, Andresdottir M, Adalsteinsdottir EA, Gislason D, Gislason T, Gurney M, Gulcher J, Stefansson K.. Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients.. PNAS. Vol 102(41) . 2005:14789-14794.
    Halapi E, Sigvaldason A, Gislason T, Hakonarson H, Hall I, Reykjavik, Iceland, Nottingham, England. A Genome Wide Screen for Smoking Susceptibility Suggests that Several Genes of Moderate Effect May Be Involved.. Am J Respir Crit Care Med. 2005.
    Helgadottir A, Manolescu A, Helgason A, Thorleifsson G, Thorsteinsdottir U, Gudbjartsson DF, Gretarsdottir S, Magnusson KP, Gudmundsson G, Hicks A, Jonsson T, Grant SF, Sainz J, O'Brien SJ, Sveinbjornsdottir S, Valdimarsson EM, Matthiasson SE, Levey AI, Abramson JL, Reilly MP, Vaccarino V, Wolfe ML, Gudnason V, Quyyumi AA, Topol EJ, Rader DJ, Thorgeirsson G, Gulcher JR, Hakonarson H, Kong A, Stefansson K.. A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction.. Am J Hum Genet. 2005.
    Halapi E, Hakonarson H.. Application of Pharmacogenomic Approaches In The Study of Drug Response in Complex Diseases.. Current Pharmacogenomics. Vol 3. 2005:87-95.
    Thakkinstian A, McEvoy M, Minelli C, Gibson P, Hancox B, Duffy D, Thompson J, Hall I, Kaufman J, Leung TF, Helms PJ, Hakonarson H, Halapi E, Navon R, Attia J.. Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review.. Am J Epidemiol. Vol 162. 2005:201-11.
    Hakonarson H.. Leukotriene B4 (LTB4)-a risk factor of heart attacks?. International Atherosclerosis Society. 2006.
    Hakonarson H.. Role of FLAP and PDE4D in Myocardial Infarction and Stroke: Target Discovery and Future Treatment Options.. Curr Treat Options Cardiovasc Med. Vol 8. 2006:183-92.
    Smith HS, Bjerregaard P, Chan HM, Corriveau A, Ebbesson SO, Etzel RA, Fabsitz RR, Hadonarson H, Hild C, Nobmann ED, Reading J, Tereshchenko L, Young TK, Howard BV.. Research with Arctic peoples: unique research opportunities in heart, lung, blood and sleep disorders. Working groupo summary and recommendations.. Int J Circumpolar Health. Vol 65. 2006:79-90.
    Arnar DO, Thorvaldsson S, Manolio T, Thorgeirsson G, Hakonarson H, Stefansson K.. Familial aggregation of atrial fibrillation in Iceland.. Eur Heart J. Vol 27. 2006:708-12.
    Helgadottir A, Manolescu A, Helgason A, Thorleifsson G, Thorsteinsdottir U, Gudbjartsson DF, Gretarsdottir S, Magnusson KP, Gudmundsson G, Hicks A, Jonsson T, Grant SF, Sainz J, O'brien SJ, Sveinbjornsdottir S, Valdimarsson EM, Matthiasson SE, Levey AI, Abramson JL, Reilly MP, Vaccarino V, Wolfe ML, Gudnason V, Quyyumi AA, Topol EJ, Rader DJ, Thorgeirsson G, Gulcher JR, Hakonarson H, Kong A, Stefansson K.. A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction.. Nat Genet. Vol 38. 2006:68-74.
    Halapi E, Hakonarson H.. Introduction to genetics.. In: Genetics of Asthma and COPD. Taylor & Francis Group LLC; 2006 (In Press).
    Hakonarson H, Halapi E.. Identification of Treatment Response Genes.. In: Pharmacogenomics. 2007.
    Wang K, Li M, Hadley D, Liu R, Glessner J, Grant SFA, Kim J, Hakonarson H, Bucan M.. High resolution copy number variation detection: application of an integrated hidden Markov Model on whole-genome SNP genotyping data.. Genome Research (In review). 2007.
    Baldassano RN, Bradfield JP, Monos DS, Kim CE, Glessner JT, Casalunovo T, Frackelton EC, Otieno FG, Kanterakis S, Shaner JL, Smith RM, Eckert AW, Robinson LJ, Onyiah CC, Abrams DJ, Chiavacci RM, Skraban R, Devoto M, Grant SF, Hakonarson H.. Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease.. Gut. Vol 56. 2007:1165-1176.
    Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, Stanley CA, Kirsch SE, Rappaport EF, Orange JS, Monos DS, Devoto M, Qu HQ, Polychronakos C.. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.. Nature. 2007 Jul.
    Grant S, Hakonarson H.. Recent development in pharmacogenomics: from candidate genes to genome-wide association studies.. Expert Rev Mol Diagn. Vol 7:4. 2007 (In Press):2-23.
    Jackson EM, Shaikh TH, Zhang F, Wainwright LM, Storm PB, Hakonarson H, Zackai EH, Biegel JA.. Atypical Teratoid/Rhabdoid Tumor in a Patient with Beckwith-Wiedemann Syndrome.. Am J Med Genet A. 29 Jun:2007.
    Baldassano RN, Bradfield JP, Monos DS, Kim CE, Glessner JT, Casalunovo T, Frackelton EC, Otieno FG, Kanterakis S, Shaner JL, Smith RM, Eckert AW, Robinson LJ, Onyiah CC, Abrams DJ, Chiavacci RM, Skraban R, Devoto M, Grant SF, Hakonarson H.. Association of Variants of the Interleukin-23 Receptor Gene With Susceptibility to Pediatric Crohn's Disease.. Clin Gastroenterol Hepatol. 5 Jul:2007.
    Grant S, Hakonarson H.. Pharmacogenetic Applications in Children.. In: Nadine Cohen. In Press.