Pathology
Located in Abramson 706, the Pathology Core unites three core components: histopathology, TMA/LCM and confocal microscopy. The core offers a full range of histopathology services, including tissue processing, embedding and cutting for both paraffin and frozen tissue. The core also performs most standard stains as well as immunohistochemistry, antibody workup, fluorescence and in situ hybridization. TMAs are constructed using a Beacher Semi-automated Arrayer. Sophisticated imaging instrumentation is available for virtual microscopy and conducting Web-based data analysis. LCM is performed with a Zeiss/P.A.L.M. instrument capable of capture from both glass slides and tissue cultures. A Leica spectral confocal system uses an acoustical-optical tunable filter for use of up to seven lasers lines, including UV. This state-of-the-art confocal microscope permits 3-D fluorescent imaging of both live and fixed specimens, and has capabilities for FRET and FRAP imaging.