Comprehensive Sickle Cell Center Philadelphia
The Comprehensive Sickle Cell Center seeks new information while applying acquired knowledge to the full benefit of the patient. To accomplish this goal the Center conducts interrelated laboratory research projects that may lead to more efficient methods of gene therapy or the development of effective anti-sickling agents. Researchers test therapeutic agents on a more realistic transgenic model for sickle cell disease and are able to evaluate the results with sophisticated image analyses systems. In the Center’s clinical projects, researchers seek to improve the nutritional and growth status of children with sickle cell disease in clinical trials using zinc and calcium and in a behavioral modification program to increase caloric intake. In addition, they are working on a long-term toxicity study of hydroxyurea therapy in children as continuation of the current Phase II study. In the era of cost-conscious health care, the Center evaluates the economic impact of a practice change in the management of the febrile child with sickle cell disease. The Center’s education programs are consolidated into one 3-part project that addresses professional education in sickle cell disease and evaluates a formal program of transition of older adolescents to adult services. In the testing and counseling area, the Center adopted the high technology microchip technology to the diagnosis of sickle cell disease at the single cell level. In addition, investigators are developing a model of culturally sensitive genetic counseling program in a newborn screening project in a developing country.