Attending Physician
Education:
M.D., Sackler School of Medicine, Tel Aviv, Israel (1997)
B.A., Smith College (1993)
B.A., Hebrew University, Jerusalem, Israel (1992)
Appointments:
Associate Professor of Pediatrics, University of Pennsylvania School of Medicine
Research Interests:
My research involves around understanding the basis of hereditary predisposition and progression of neuroblastoma. Recently we have reported our discovery of ALK as a critical neuroblastoma oncogene and mutations of which are inherited as well as acquired by the tumor cells. We have have already completed preclinical testing of a variety of ALK inhibitors through our numerous research collaborative agreements with industry, and have ongoing Phase 1 clinical trial. Further, we are working towards ALK based inhibition therapies that combines our knowledge of structural and biochemical features of ALK with clinically identified mutations. We will use this information to design screens for compounds that inhibit common ALK mutants resistant to current therapeutic agents. Having previously discovered mutations in PHOX2B as the cause of neuroblastoma that occurs with other disorders of the neural crest, we are now focused on translation of these discoveries.
Selected Recent Publications:
- Diskin SJ, Hou C, Glessner JT, Attiyeh EF, Laudenslager M, Bosse K, Cole K, Mossé YP, Wood A, Lynch JE, Pecor K, Diamond M, Winter C, Wang K, Kim C, Geiger EA, McGrady PW, Blakemore AI, London WB, Shaikh TH, Bradfield J, Grant SF, Li H, Devoto M, Rappaport ER, Hakonarson H, Maris JM. Copy number variation at 1q21.1 associated with neuroblastoma. Nature. 2009
- 2: Capasso M, Devoto M, Hou C, Asgharzadeh S, Glessner JT, Attiyeh EF, Mosse YP, Kim C, Diskin SJ, Cole KA, Bosse K, Diamond M, Laudenslager M, Winter C, Bradfield JP, Scott RH, Jagannathan J, Garris M, McConville C, London WB, Seeger RC, Grant SF, Li H, Rahman N, Rappaport E, Hakonarson H, Maris JM. Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. Nat Genet. 2009
- Attiyeh EF, Diskin SJ, Attiyeh MA, Mossé YP, Hou C, Jackson EM, Kim C, Glessner J, Hakonarson H, Biegel JA, Maris JM. Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy. Genome Res. 2009
- Mossé YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, Laquaglia MJ, Sennett R, Lynch JE, Perri P, Laureys G, Speleman F, Kim C, Hou C, Hakonarson H, Torkamani A, Schork NJ, Brodeur GM, Tonini GP, Rappaport E, Devoto M, Maris JM. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature. 2008
- Huang J, Marcus CL, Bandla P, Schwartz MS, Pepe ME, Samuel JM, Panitch HB, Bradford RM, Mosse YP, Maris JM, Colrain IM. Cortical processing of respiratory occlusion stimuli in children with central hypoventilation syndrome. Am J Respir Crit Care Med. 2008
- Cole KA, Attiyeh EF, Mosse YP, Laquaglia MJ, Diskin SJ, Brodeur GM, Maris JM. A functional screen identifies miR-34a as a candidate neuroblastoma Tumor Suppressor Gene. Mol Cancer Res. 2008
- Huang J, Colrain IM, Panitch HB, Tapia IE, Schwartz MS, Samuel J, Pepe M, Bandla P, Bradford R, Mosse YP, Maris JM, Marcus CL. Effect of sleep stage on breathing in children with central hypoventilation. J Appl Physiol. 2008
- Maris JM, Mosse YP, Bradfield JP, Hou C, Monni S, Scott RH, Asgharzadeh S, Attiyeh EF, Diskin SJ, Laudenslager M, Winter C, Cole KA, Glessner JT, Kim C, Frackelton EC, Casalunovo T, Eckert AW, Capasso M, Rappaport EF, McConville C, London WB, Seeger RC, Rahman N, Devoto M, Grant SF, Li H, Hakonarson H. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. N Engl J Med. 2008
- Mosse YP, Diskin SJ, Wasserman N, Rinaldi K, Attiyeh EF, Cole K, Jagannathan J, Bhambhani K, Winter C, Maris JM. Neuroblastomas have distinct genomic DNA profiles that predict clinical phenotype and regional gene expression. Genes Chromosomes Cancer. 2007
Yael P. Mossé, MD