header imageJohn M. Maris M.D

John M. Maris M.D
Principal Investigator
Education:

Dr. Maris has a M.D from University of Pennsylvania in Pediatrics and a B.S in Biology from Wheeling College.

Appointments:

He is currently the Chief of Division of Oncology and Director of the Center for Childhood Cancer Research at the Children's Hospital of Pennsylvania and an Associate Professor of Pediatrics at the University Of Pennsylvania School Of Medicine. He is also an attending physician at the Oncology clinic at the Children’s Hospital of Philadelphia.

Selected awards and honors include:
  • 1988 Alpha Omega Alpha
  • 1989 Pincus Award: Outstanding Clinician of Graduating Medical Class or Award
  • 2004 Elected to the Society of Pediatric Research
  • 2007 Oski Award, American Society of Pediatric Hematology/Oncology
  • 2007 Elected to the American Society of Clinical Investigation
  • 2007 Giulio D'Angio Endowed Chair in Neuroblastoma Research, Children's Hospital of Philadelphia
  • 2009 Leonard Berwick Memorial Teaching Award, University of Pennsylvania School of Medicine
Research Interests:

Dr. Maris is a physician-scientist and his basic research program is anchored in the genetics and genomics of neuroblastoma. The four main themes in his lab are (1) determining the genetic events that initiate neuroblastoma tumorigenesis; (2) determining the somatically acquired genomic aberrations and genes responsible for the diverse clinical phenotype observed in patients with neuroblastoma; (3) using genetic approaches to define the unique features of neuroblastoma vascular biology, including functional validation in murine models and applied research with novel compounds targeting neuroblastoma vasculature in partnership with industry; and (4) developing array-based high throughput methods for solid tumor molecular diagnostics.

Selected Recent Publications:
  • Diskin SJ, Hou C, Glessner JT, Attiyeh EF, Laudenslager M, Bosse K, Cole K, Mossé YP, Wood A, Lynch JE, Pecor K, Diamond M, Winter C, Wang K, Kim C, Geiger EA, McGrady PW, Blakemore AI, London WB, Shaikh TH, Bradfield J, Grant SF, Li H, Devoto M, Rappaport ER, Hakonarson H, Maris JM. Copy number variation at 1q21.1 associated with neuroblastoma. Nature. 2009 Jun 18;459(7249):987-91. PubMed PMID:19536264.
  • Capasso M, Devoto M, Hou C, Asgharzadeh S, Glessner JT, Attiyeh EF, Mosse YP, Kim C, Diskin SJ, Cole KA, Bosse K, Diamond M, Laudenslager M, Winter C, Bradfield JP, Scott RH, Jagannathan J, Garris M, McConville C, London WB, Seeger RC, Grant SF, Li H, Rahman N, Rappaport E, Hakonarson H, Maris JM. Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. Nat Genet. 2009 Jun;41(6):718-723. Epub 2009 May 3. PubMed PMID: 19412175.
  • Attiyeh EF, Diskin SJ, Attiyeh MA, Mossé YP, Hou C, Jackson EM, Kim C, Glessner J, Hakonarson H, Biegel JA, Maris JM. Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy. Genome Res. 2009 Feb;19(2):276-83. Epub 2009 Jan 13. Erratum in: Genome Res. 2009 Mar;19(3):520. PubMed PMID: 19141597; PubMed Central PMCID: PMC2652209.
  • Mossé YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, Laquaglia MJ, Sennett R, Lynch JE, Perri P, Laureys G, Speleman F, Kim C, Hou C, Hakonarson H, Torkamani A, Schork NJ, Brodeur GM, Tonini GP, Rappaport E, Devoto M, Maris JM. Identification of ALK as a major familial neuroblastoma predisposition gene. Nature. 2008 Oct 16;455(7215):930-5. Epub 2008 Aug 24. PubMed PMID: 18724359; PubMed Central PMCID: PMC2672043.
  • Cole KA, Attiyeh EF, Mosse YP, Laquaglia MJ, Diskin SJ, Brodeur GM, Maris JM. A functional screen identifies miR-34a as a candidate neuroblastoma Tumor Suppressor Gene. Mol Cancer Res. 2008 May;6(5):735-42. PubMed PMID: 18505919
  • Maris JM, Mosse YP, Bradfield JP, Hou C, Monni S, Scott RH, Asgharzadeh S, Attiyeh EF, Diskin SJ, Laudenslager M, Winter C, Cole KA, Glessner JT, Kim C, Frackelton EC, Casalunovo T, Eckert AW, Capasso M, Rappaport EF, McConville C, London WB, Seeger RC, Rahman N, Devoto M, Grant SF, Li H, Hakonarson H. Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. N Engl J Med. 2008 Jun 12;358(24):2585-93. Epub 2008 May 7. PubMed PMID: 18463370.

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