Research Publications
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- Scavenger Receptor Class B Type I-mediated Cholesteryl Ester-selective Uptake and Efflux of Unesterified Cholesterol. Influence of High Density Lipoprotein Size and Structure
J. Biol. Chem., 13: 12448-12455 (2004)
S.T. Thuahnai, S. Lund-Katz, P. Dhanasekaran, M. de la Llera-Moya, M.A. Connelly, D.L. Williams, G.H. Rothblat, M.C. Phillips - Helix Orientation of the Functional Domains in Apolipoprotein E in Discoidal High Density Lipoprotein Particles
J. Biol. Chem., 14: 14273-14279 (2004)
V. Narayanaswami, J.N. Maiorano, P. Dhanasekaran, R.O. Ryan, M.C. Phillips, S. Lund-Katz, W.S. Davidson - Alpha-helix Formation is Required for High Affinity Binding of Human Apolipoprotein A-I to Lipids
J. Biol. Chem., 279: 20974-20981 (2004)
H. Saito, P. Dhanasekaran, D. Nguyen, E. Deridder, P. Holvoet, S. Lund-Katz, M.C. Phillips - Identification of an Apolipoprotein A-I Structural Element that Mediates Cellular Cholesterol Efflux and Stabilizes ATP Binding Cassette Transporter A1
J. Biol. Chem., 279: 24044-24052 (2004)
P. Natarajan, T.M. Forte, B. Chu, M.C. Phillips, J.F. Oram, J.K. Bielicki - Influence of ApoA-I Structure on the ABCA1-mediated Efflux of Cellular Lipids
J. Biol. Chem. 279: 49931-49939 (2004)
Vedhachalam, C., Liu, L., Nickel, M., Dhanasekaran, P., Anantharamaiah, G.M., Lund-Katz, S., Rothblat, G.H., Phillips, M.C. - Sensitivity of volume-regulated anion current to cholesterol structural analogues
J. Gen. Physiol. 123: 77-87 (2004)
Romanenko, V.G., Rothblat, G.H., Levitan, I. - Glycine 420 near the C-terminal transmembrane domain of SR-BI is critical for proper delivery and metabolism of high density lipoprotein cholesteryl ester
J. Biol. Chem. 279: 24976-24985 (2004)
Parathath, S., Sahoo, D., Darlington, Y.F., Peng, Y., Collins, H.L., Rothblat, G.H., Williams, D.L., Connelly, M.A. - SR-BI-and ABCA1-mediated cholesterol efflux to serum from patients with Alagille syndrome
J. Lipid Res. 45: 1724-1732 (2004)
Yancey, P.G., Asztalos, B., Stettler, N., Piccoli, D., Williams, D., Connelly, M., Rothblat, G. - Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells
Biochem. Biophys. Res. Comm.321: 670-674 (2004)
Zanotti, I. Favari, E., Sposito, A., Rothblat, G.H., Bernini, F. - Changes in Plasma Membrane Properties and Phosphatidylcholine Subspecies of Insect Sf9 Cells due to Expression of Class B Scavenger Receptor SR-BI and CD36
J. Biol. Chem. 279:41310-41318 (2004)
Parathath, S., Connelly, M.A., Rieger, R.A., Klein, S.M. Aburmrad, A., de la Llera-Moya, M., Ident, C.R., Rothblat, G.H., Williams, D.L. - Scavenger Receptor BI (SR-BI) Clustered on Microvillar Extensions Suggests that this Plasma Membrane Domain is a Way Station for Cholesterol Trafficking between Cells and High Density Lipoprotein
Mol. Biol. Cell 15: 384-396 (2004)
Peng, Y, Akmentin, W., Connelly, M.A., Lund-Katz, S., Phillips, M.C., Williams, D.L. - Antimitogenic Effects of HDL and ApoE Mediated by Cox-2-dependent IP Activation
J. Clin. Invest. 113: 609-618 (2004)
Kothapalli, D., Fuki, I., Ali, K., Stewart, S.A., Zhao, L., Yahil, R., Kwiatkowski, D., Hawthorne, E.A., FitzGerald, G.A., Phillips, M.C., Lund-Katz, S., Pure, E., Rader, D.J. and Assoian, R.K. - Structure of Human Apolipoprotein A-IV: A Distinct Domain Architecture Among Exchangeable Apolipoproteins with Potential Functional Implications
Biochemistry 43(33): 10719-10729 (2004)
Pearson, K., Saito, H., Woods, S.C., Lund-Katz, S., Tso, P., Phillips, M.C., Davidson, W.S. - Aromatic Residue Position on the Nonpolar Face of Class A Amphipathic Helical Peptides Determines Biological Activity
J. Biol. Chem. 279(25): 26509-26517 (2004)
Datta, G., Epand, R.F., Epand, R.M., Chaddha, M., Kirksey, M.A., Garber, D.W., Lund-Katz, S., Phillips, M.C., Hama, S., Navab, M., Fogelman, A.M., Palgunachari, M.N., Segrest, J.P., Anantharamaiah, G.M. - Apolipoprotein A-I-stimulated apolipoprotein E secretion from human macrophages is independent of cholesterol efflux
J. Biol. Chem. 279(25): 25966-25977 (2004)
Kockx, M., Rye, K.A., Gaus, K., Quinn, C.M. Wright, J., Sloane, T., Sviridov, D., Fu, Y., Sullivan, D., Burnett, J.R., Rust, S., Assmann, G., Anantharamaiah, G.M., Palgunachari, M.N., Lund-Katz, S., Phillips, M.C., Dean, R.T., Jessup, W., Kritharides, L. - Class B Scavenger Receptor-Mediated Intestinal Absorption of Dietary ?-Carotene and Cholesterol
Biochemistry, 44: 4517-4525 (2005)
Van Bennekum, A., Werder, M., Thuahnai, S.T., Han, C-H., Duong, P., Williams, D.L., Wettstein, P., Schulthess, G., Phillips, M.C., Hauser, H. - Two-step Mechanism of Binding of Apolipoprotein E to Heparin: Implications for the Kinetics of Apolipoprotein E-heparan Sulfate Proteoglycans Complex Formation on Cell Surfaces
J. Biol. Chem. 280: 5414-5422 (2005)
Futamura, M., Dhanasekaran, P., Handa, T., Phillips, M.C., Lund-Katz, S., Saito, H. - Effects of the Core Lipid on the Energetics of Binding of ApoA-I to Model Lipoprotein Particles of Different Sizes
Biochemistry, 44: 10689-10695 (2005)
Tanaka, M., Saito, H., Dhanasekaran, P., Wehrli, S., Handa, T., Lund-Katz, S., Phillips, M.C. - Differential effects of the HDL subpopulations on cellular ABCA1- and SRB1-mediated cholesterol efflux
J Lipid Res. 46:2246-2253 (2005)
Asztalos BF, de la Llera-Moya M, Dallal GE, Horvath KV, Schaefer EJ, Rothblat GH. - Pulmonary abnormalities due to ABCA1 deficiency in mice
Am J Physiol ; 289:980-989 (2005)
Bates SR, Tao J-Q, Collins HL, Francone OL, Rothblat GH. - Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation
Circulation Research; 97:763-771 (2005)
Moore RE, Navab M, Millar JS, Zimetti F, Hama S, Rothblat GH, Rader DJ. - Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
J Clin Invest; 115:2870-2874 (2005)
Zhang Y-Z, da Silva JS, Reilly M, Billheimer JT, Rothblat GH, Rader DJ. - Effect of Carboxyl-Terminal Truncation on Structure and Lipid Interaction of Human Apolipoprotein E4
Biochemistry, 45: 4240-4247 (2006)
Tanaka, M., Vedhachalam, C., Sakamoto, T., Dhanasekaran, P., Phillips, M.C., Lund-Katz, S., Saito, H - Contributions of the N- and C-Terminal Helical Segments to the Lipid-Free Structure and Lipid Interaction of Apolipoprotein A-I
Biochemistry 45: 10351-10358 (2006)
Tanaka, M., Dhanasekaran, P., Nguyen, D., Ohta, S., Lund-Katz, S., Phillips, M.C., Saito, H. - Characterization of Nascent HDL Particles and Microparticles Formed by ABCA1-Mediated Efflux of Cellular Lipids to ApoA-I
J. Lipid Res. 47: 832-843 (2006)
Duong, P.T., Collins, H.L., Nickel, M., Lund-Katz, S., Rothblat, G.H., Phillips, M.C. - Pharmacologic activation of liver X receptors promotes reverse cholesterol transport in vivo
Circulation 113:90-97 (2006)
Naik SU, da Silva JS, Jaye M, Macphee CH, Billheimer JT, Rothblat GH, Rader DJ. - Segregation of micron-scale membrane sub-domains in live murine sperm
J. Cellular Physiology, 206:636-646 (2006)
Selvaraj V, Asano A, Buttke De, McElwee JL, Nelson JL, Wolff A, Merdiushev T, Formes MW, Cohen AW, Lisanti MP, Rothblat GH, Kopf GS, Travis AJ. - Gene expression changes in foam cells and the role of chemokine receptor CCR& during atherosclerosis regression in apoE-deficient mice
Proc. Natl. Acad. Sci., 103:3781-3786 (2006)
Trogan E, Feig JE, Dogan S, Rothblat GH, Angeli V, Tacke F, Randolph GJ, Fisher EA. - The relative contributions of ABCA1 and SR-BI to cholesterol efflux to serum from fibroblasts and macrophages
Arterioscler.Thromb.and Vascular Biol. 26:541-547 (2006)
Duong M-N, Jin W, Zanotti I, Favari E, Rothblat GH. - Measurement of cholesterol bidirectional flux between cells and lipoproteins
J. Lipid Res.,47:605-613 (2006)
Zimetti F, Weibel GK, Duong M-N, Rothblat GH.
