Research
The Laboratory for Applied PK/PD, in conjunction with the mission of the Division of Clinical Pharmacology and Therapeutics, is focused on the investigation of sources of variation in pediatric pharmacokinetics and pharmacodynamics. Applied clinical pharmacologic investigation coupled with modeling and simulation strategies are pursued with the intention of developing rational dosing guidance in various pediatric populations for both marketed and exploratory compounds. Clinical trial simulation is to be utilized prospectively to explore design dependencies and parameter sensitivities. The Laboratory is also focused on the development of pharmacometric approaches to advance PK/PD, novel biomarker development and disease progression modeling.
Some of the drugs that we're actively studying include:
Midazolam
Sodium Nitroprusside
Actinomycin-D
Methotrexate
Fluconazole
Dexmedetomidine